MODEL QUALIFICATION METHOD RELEVANCE 1. MODEL SCOPE IS RELEVANT FOR RESEARCH CONTEXT 2. MODEL REPRESENTS RELEVANT BIOLOGICAL MECHANISMS UNCERTAINTY 3. RELEVANT QUALITATIVE UNCERTAINTIES ARE ASSESSED 4. RELEVANT QUANTITATIVE UNCERTAINTIES ARE ADDRESSED VARIABILITY 5. MODEL CAPTURES RELEVANT KNOWN PATHWAY VARIABILITIES 6. RELEVANT CLINICAL VARIABILITY IS REPRODUCED DATA 7. MODEL RESULTS ARE QUALITATIVELY CONSISTENT WITH RELEVANT DATA AND KNOWLEDGE 8. MODEL MATCHES RELEVANT PRE-SPECIFIED QUANTITATIVE TEST DATA

Description of Design Search

The mark consists of an inner circle with the literal element "Model Qualification Method" printed in black; an outer circle comprised of eight wedges. The upper right two wedges in blue contain the literal elements "1. Model scope is relevant for research context" and "2. Model represents relevant biological mechanisms." The lower right two wedges in green contain the literal elements "3. Relevant qualitative uncertainties are assessed" and "4. Relevant quantitative uncertainties are assessed." The lower left two wedges in rose-pink contain the literal elements "5. Model captures relevant known pathway variabilities" and "6. Relevant clinical variability is reproduced." The upper left two wedges in orange contain the literal elements "7. Model results are qualitatively consistent with relevant data knowledge" and "8. Model matches relevant pre-specified quantitative test data." All literal elements within the wedges are printed in black. Outside each quadrant are the literal elements "Relevance" in blue, "Uncertainty" in green, "Variability" in rose-pink, and "Data" in orange.